Inhibition of osteoclastogenesis by a phosphodiesterase 4 inhibitor XT-611 through synergistic action with endogenous prostaglandin E₂YAMAGAMI, Hideomi; NISHIOKA, Tatsuo; OCHIAI, Eiji et al.Biochemical pharmacology. 2003, Vol 66, Num 5, pp 801-807, issn 0006-2952, 7 p.Article

Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitorsBADLAND, Matthew; DEVILLERS, Ingrid; WRIGGLESWORTH, Roger et al.Tetrahedron letters. 2011, Vol 52, Num 41, issn 0040-4039, 5202, 5292-5296 [6 p.]Article

Cyclic nucleotide phosphodiesterase-4 inhibitors: a promising therapeutic approach to premature birth?MEHATS, Céline; OGER, Stéphanie; LEROY, Marie-Josèphe et al.European journal of obstetrics, gynecology, and reproductive biology. 2004, Vol 117, pp S15-S17, issn 0301-2115, SUP1Conference Paper

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitorsPACKARD, Garrick K; PAPA, Patrick; MCCARRICK, Margaret A et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 747-752, issn 0960-894X, 6 p.Article

Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4BHASKAR KUMAR, T; SUMANTH, Ch; SHIVA KUMAR, K et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 17, pp 5639-5647, issn 0960-894X, 9 p.Article

Combined anti-inflammatory effects of β₂-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMPCHRISTIANSEN, S. H; SELIGE, J; DUNKERN, T et al.Neurochemistry international. 2011, Vol 59, Num 6, pp 837-846, issn 0197-0186, 10 p.Article

Phosphodiesterase Inhibition in Heart FailureMOVSESIAN, Matthew A; KUKREJA, Rakesh C.Handbook of experimental pharmacology. 2011, Vol 204, pp 237-249, issn 0171-2004, 13 p.Article

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slicesWOHLSEN, Andrea; HIRRLE, Andrea; TENOR, Hermann et al.European journal of pharmacology. 2010, Vol 635, Num 1-3, pp 177-183, issn 0014-2999, 7 p.Article

Time-dependent involvement of cAMP and cGMP in consolidation of object memory : Studies using selective phosphodiesterase type 2, 4 and 5 inhibitorsRUTTEN, Kris; PRICKAERTS, Jos; HENDRIX, Martin et al.European journal of pharmacology. 2007, Vol 558, Num 1-3, pp 107-112, issn 0014-2999, 6 p.Article

Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of actionRUTTEN, K; PRICKAERTS, J; BLOKLAND, A et al.Neurobiology of learning and memory (Print). 2006, Vol 85, Num 2, pp 132-138, issn 1074-7427, 7 p.Article

Phosphodiesterase 4b (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitroAHMED, T; FREY, J. U.Brain research. 2005, Vol 1041, Num 2, pp 212-222, issn 0006-8993, 11 p.Article

Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor VII294A in healthy volunteersDONIGI GALE, Donna; LANDELLS, Linda J; PAGE, Clive P et al.British journal of clinical pharmacology. 2002, Vol 54, Num 5, pp 478-484, issn 0306-5251, 7 p.Article

Recent Advances on Phosphodiesterase 4 Inhibitors for the Treatment of Asthma and Chronic Obstructive Pulmonary DiseaseKODIMUTHALI, Arumugam; SUGIN LAL JABARIS, S; PAL, Manojit et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 18, pp 5471-5489, issn 0022-2623, 19 p.Article

C-C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl) quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitorsSHIVA KUMAR, K; KIRAN KUMAR, S; PAL, Manojit et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 7, pp 2199-2207, issn 0968-0896, 9 p.Article

Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C-Cu catalysisRAO GORJA, Dhilli; SHIVA KUMAR, K; KANDALE, Ajit et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 7, pp 2480-2487, issn 0960-894X, 8 p.Article

Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in ratsPETER, D; GÖGGEL, R; COLBATZKY, F et al.British journal of pharmacology. 2011, Vol 162, Num 2, pp 415-427, issn 0007-1188, 13 p.Article

THE NOVEL DISTRIBUTION OF PHOSPHODIESTERASE-4 SUBTYPES WITHIN THE RAT RETINAWHITAKER, C. M; COOPER, N. G. F.Neuroscience. 2009, Vol 163, Num 4, pp 1277-1291, issn 0306-4522, 15 p.Article

Phosphodiesterase genes and antidepressant treatment response : A reviewESPOSITO, Karin; REIERSON, Gillian W; HUAI RONG LUO et al.Annals of medicine (Helsinki). 2009, Vol 41, Num 3, pp 177-185, issn 0785-3890, 9 p.Article

PDE4 inhibitors : current status. CommentaryGIEMBYCZ, M. A; SPINA, D.British journal of pharmacology. 2008, Vol 155, Num 3, issn 0007-1188, 288-290, 308-315 [11 p.]Article

Suppression of detrusor overactivity in rats with bladder outlet obstruction by a type 4 phosphodiesterase inhibitorNISHIGUCHI, Jun; DONG DEUK KWON; KAIHO, Yasuhiro et al.BJU international (Papier). 2007, Vol 99, Num 3, pp 680-686, issn 1464-4096, 7 p.Article

Phosphodiesterase inhibitorsBOSWELL-SMITH, Victoria; SPINA, Domenico; PAGE, Clive P et al.British journal of pharmacology. 2006, Vol 147, issn 0007-1188, S252-S257, SUP1Article

Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization studyMIRO, Xavier; PEREZ-TORRES, Silvia; ARTIGAS, Francesc et al.Neuropharmacology. 2002, Vol 43, Num 7, pp 1148-1157, issn 0028-3908, 10 p.Article

Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4RAM REDDY, T; RAJESHWAR REDDY, G; SRINIVASULA REDDY, L et al.European journal of medicinal chemistry. 2012, Vol 48, pp 265-274, issn 0223-5234, 10 p.Article

Etazolate improves performance in a foraging and homing task in aged ratsDROTT, Jason; DESIRE, L; DROUIN, D et al.European journal of pharmacology. 2010, Vol 634, Num 1-3, pp 95-100, issn 0014-2999, 6 p.Article

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitorsSKOUMBOURDIS, Amanda P; LECLAIR, Christopher A; MICHNICK, Stephen W et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 13, pp 3686-3692, issn 0960-894X, 7 p.Article